Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology

Autor: Eleonora Gori, Alessio Pierini, Valentina Meucci, Francesca Abramo, Luisa V. Muscatello, Veronica Marchetti
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 35, Iss 4, Pp 1773-1779 (2021)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16149
Popis: Abstract Background Although the influence of copper ([Cu]) on chronic hepatitis (CH) has been widely studied in dogs, little information is available about the accumulation of other metals. Hypothesis/Objectives We assessed the concentration of lead ([Pb]) in the livers of dogs with CH with or without abnormal hepatic [Cu] to establish if any association existed between [Pb] and either hematologic or biochemical variables, fibrosis, necrosis and inflammation of the liver on histology. Animals Thirty‐four dogs with CH that had hepatic [Cu] and [Pb] determined. Methods Retrospective review of medical records of dogs with CH and hepatic [Cu] and [Pb]. Chronic hepatitis was defined using current American College of Veterinary Internal Medicine consensus statement guidelines. Hepatic [Cu] and [Pb] were determined using square wave anodic stripping voltammetry. Dogs were divided into 2 groups based on [Cu]:
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