| Autor: |
Wiesje Pelkmans, Nienke Legdeur, Mara tenKate, Frederik Barkhof, Maqsood M. Yaqub, Henne Holstege, Bart N. M. vanBerckel, Philip Scheltens, Wiesje M. van derFlier, Pieter Jelle Visser, Betty M. Tijms |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 348-358 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2328-9503 |
| DOI: |
10.1002/acn3.51273 |
| Popis: |
Abstract Objective To investigate the relationship between amyloid‐β (Aβ) deposition and markers of brain structure on cognitive decline in oldest‐old individuals with initial normal cognition. Methods We studied cognitive functioning in four domains at baseline and change over time in fifty‐seven cognitively intact individuals from the EMIF‐AD 90+ study. Predictors were Aβ status determined by [18F]‐flutemetamol PET (normal = Aβ − vs. abnormal = Aβ+), cortical thickness in 34 regions and hippocampal volume. Mediation analyses were performed to test whether effects of Aβ on cognitive decline were mediated by atrophy of specific anatomical brain areas. Results Subjects had a mean age of 92.7 ± 2.9 years, of whom 19 (33%) were Aβ+. Compared to Aβ−, Aβ+ individuals showed steeper decline on memory (β ± SE = −0.26 ± 0.09), and processing speed (β ± SE = −0.18 ± 0.08) performance over 1.5 years (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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