| Autor: |
S.T. Latha, S. Ananda Thangadurai, M. Jambulingam, K. Sereya, D. Kamalakannan, M. Anilkumar |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 10, Iss S1, Pp S1138-S1144 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2013.02.006 |
| Popis: |
In this study, a simple, precise and accurate reverse phase high performance liquid chromatography was developed for the estimation of Erlotinib in bulk and pharmaceutical dosage forms. A reverse phase Merck C18 column (250 cm × 4.6 mm × 5 μm) with mobile phase consisting of potassium dihydrogen orthophosphate and acetonitrile (70:30 V/V) having pH 5.0 was adjusted with orthophosphoric acid was used. The flow rate was 0.8 mL min−1 and the effluents were monitored at 246 nm. The retention time was found to be 4.54 min. The linearity of the drug was obtained in the range of 10–60 μg mL−1. The results of analysis have been validated according to ICH guideline requirements for registration of human use. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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