Association of CRP gene polymophism with CRP levels and Coronary Artery Disease in Type 2 Diabetes in Ahwaz,Southwest of Iran
| Autor: | Mohammad Ali Ghaffari, Saeed Askari Sede, Nadereh Rashtchizadeh, Ghorban Mohammadzadeh, Shahla Majidi |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | BioImpacts, Vol 4, Iss 3, Pp 133-139 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2228-5652 2228-5660 |
| DOI: | 10.15171/bi.2014.006 |
| Popis: | Introduction: We evaluated the association between four polymorphisms in the CRP gene with plasma C-reactive protein (CRP) levels,prevalence and severity of coronary artery disease(CAD) in type 2 diabetes mellitus (T2DM)patients. Methods: We performed coronary angiography for 308 T2DM patients and classified them into two groups: T2DM with CAD and T2DM without CAD, all patient come from Ahwaz, Iran. Plasma levels of CRP, glucose and lipid profile were measured. Genotyping was performed by PCR/RFLP, and the severity of coronary artery disease was determined by Gensini score. Results: The GG genotype of SNP rs279421 was associated with increased risk CAD (OR = 2.38; 95%CI: 1.12- 5.8; P = 0.02)and CA,TT,TA genotypes and A allele of SNP rs3091244 and GA genotypes and A allele of SNP rs3093062 were significantly associated with increased CRP levels.None genotypes or alleles was not associated with Gensini score. We found that the haplotype 7 (AGCG) was associated with decreased risk of CAD (OR = 0.11; 95%CI: 0.02, 0.66; P = 0.017) . The Gensini score was correlated with increased levels of CRP, only in CAD group. Conclusion: Although genetic polymorphisms were influenced on plasma CRP levels but none of the alleles and genotypes raising or falling C-reactive protein levels was consistently associated with an increased prevalence of CAD or protected from that. |
| Databáze: | Directory of Open Access Journals |
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