Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice
| Autor: | Ya-Xuan Sun, Ting Liu, Xue-Ling Dai, Ya-Bo Li, Yu-Yao Li, Hua Zhang, Li-Zhe An |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Journal of Chemistry, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-9063 2090-9071 |
| DOI: | 10.1155/2014/373872 |
| Popis: | The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities. |
| Databáze: | Directory of Open Access Journals |
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