Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis
| Autor: | Carla Wanderley Gayoso, Edeltrudes de Oliveira Lima, Evandro Leite de Souza, Valdir Cechinel Filho, Vinícius Nogueira Trajano, Fillipe de Oliveira Pereira, Igara Oliveira Lima |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Brazilian Archives of Biology and Technology, Vol 49, Iss 4, Pp 661-664 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1516-8913 1678-4324 |
| DOI: | 10.1590/S1516-89132006000500016 |
| Popis: | This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100µg/mL for 3,4-dichloro-N-phenyl-methyl-maleimide and 3,4-dichloro-N-phenyl-propil-maleimide and 200µg/mL for 3,4-dichloro-N-phenyl-maleimide, 3,4-dichloro-N-phenyl-ethyl-maleimide and 3,4-dichloro-N-phenyl-buthyl-maleimide.Este estudo objetivou analisar a efetividade de maleimidas como inibidores do crescimento de cepas fúngicas isoladas de onicomicoses através da técnica de difusão em meio sólido. Os resultados mostraram destacável atividade antifúngica das maleimidas ensaiadas com a formação de halos de inibição do crescimento fúngico com diâmetros oscilando entre 10 e 23mm. A CIM encontrada foi 100µg/mL para 3,4-dicloro-N-fenil-metil-maleimida e 3,4-dicloro-N-fenil-propil-maleimida e 200µg/mL para 3,4-dicloro-N-fenil-maleimida, 3,4-dicloro-N-fenil-etil-maleimida e 3,4-dicloro-N-fenil-butil-maleimida. |
| Databáze: | Directory of Open Access Journals |
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