Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agent

Autor:	Bhabal Sonal R., Shaikh Sarfaraz F., Yellapurkar Ishita P., Pavale Ganesh S., Ramana Mucheli M. V.
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	in vitro cancer cell line breast cancer cell line liver cancer cell line prostate cancer cell line Chemistry QD1-999
Zdroj:	Journal of the Serbian Chemical Society, Vol 87, Iss 10, Pp 1109-1116 (2022)
Druh dokumentu:	article
ISSN:	0352-5139 1820-7421
DOI:	10.2298/JSC210428041B
Popis:	A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity. The in vitro anticancer activity of the synthesized compounds 4a–h was evaluated against four human cancer cell lines namely lung (A549), breast (MCF-7), liver (HEPG2) and prostate (PC-3). Compounds 4c, 4d, 4g and 4h exhibited good activity with GI50
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4e60abc7f71942efa3e315a95b0b6c54 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF