Assessment of estrous cycle, ovarian and uterine tissue and fetal parameters of Wistar rats treated with Topiramate
| Autor: | Isabel Cristina Cherici Camargo, Willian Eduardo Neres, Ana Paula Queiroz Mello, Vinicius Augusto Simão |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Semina: Ciências Biológicas e da Saúde, Vol 37, Iss 2, Pp 55-70 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1676-5435 1679-0367 |
| DOI: | 10.5433/1679-0367.2016v37n2p55 |
| Popis: | Topiramate (TPM) is included in the newer generation of antiepileptic drugs and is known to have multiple mechanisms of action. The drug has also been used for reducing body weight. Its effect on reproductive tissues and estrous cycle deserve greater attention. Then, this study aimed to investigate possible effects of the drug on ovarian and uterine tissues, estrous cycle and some fetal parameters of non-epileptic Wistar rats. In Experiment I, females received tap water (C - Control group; n=8) or Topiramate (TPM group; 100 mg/kg; n=8), orally for 6 weeks. The estrous cycle and food consumption were monitored. Ovarian and uterine sections were examined under light microscopy. In Experiment II, pregnant rats of C and TPM groups received treatments during the pre-implantation, implantation or organogenesis period. In females of Experiment I, TPM had no effect on the food consumption, final body weight, weekly body weight and estrous cycle. Ovarian and uterine weight was similar in both groups. The kinetics of folliculogenesis was unaffected by treatment with the drug. There was a significant (p |
| Databáze: | Directory of Open Access Journals |
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