Role of Exosomes in Brain Diseases

Autor: Nan Zhang, Fengling He, Ting Li, Jinzhi Chen, Liping Jiang, Xin-Ping Ouyang, Lielian Zuo
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Cellular Neuroscience, Vol 15 (2021)
Druh dokumentu: article
ISSN: 1662-5102
DOI: 10.3389/fncel.2021.743353
Popis: Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.
Databáze: Directory of Open Access Journals