Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor

Autor: Takashi Ueda, Ippei Takada, Teruki Shimizu, Saya Ito, Atsuko Fujihara, Takumi Shiraishi, Terukazu Nakamura, Osamu Ukimura
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: IJU Case Reports, Vol 5, Iss 4, Pp 247-250 (2022)
Druh dokumentu: article
ISSN: 2577-171X
DOI: 10.1002/iju5.12446
Popis: Introduction Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non‐seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy. Case presentation A 36‐year‐old man was admitted to the hospital with pancytopenia. Previously, he had received intensive care for an advanced left testicular germ cell tumor. Although multidisciplinary treatments including several regimens of salvage chemotherapy, desperation retroperitoneal lymph node dissection, and focal radiotherapy were performed, the serum tumor marker alfa‐fetoprotein was not normalized and there were no findings of relapse by several imaging modalities. Bone marrow aspirate, conducted to diagnose a cause of pancytopenia, revealed metastatic germ cell tumors in the bone marrow. Conclusion Bone marrow metastasis should be considered as a differential diagnosis in patients with germ cell tumors whose serum tumor makers are not normalized without any radiographic finding of recurrence.
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