Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma

Autor: Xiao-Yan Ming, Li Fu, Li-Yi Zhang, Yan-Ru Qin, Ting-Ting Cao, Kwok Wah Chan, Stephanie Ma, Dan Xie, Xin-Yuan Guan
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13568
Popis: There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling.
Databáze: Directory of Open Access Journals