| Autor: |
Ana-Maria Sigarteu Chindris, Michael Rivera, Yaohua Ma, Asha Nair, Yi Liu, Xue Wang, Brian M. Necela, Jennifer M. Kachergus, John D. Casler, Christopher Brett, Ana M. Rivas Mejia, Victor J. Bernet, John A. Copland, Keith L. Knutson, E. Aubrey Thompson, Robert C. Smallridge |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Endocrinology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2024.1440722 |
| Popis: |
IntroductionBRAFV600E mutation (BRAFmut) is common in papillary thyroid cancer (PTC), and most patients have an excellent outcome. However, a TERT-promoter mutation (pTERTmut) in the presence of BRAFmut (BRAFmutpTERTmut) has been demonstrated to confer a more aggressive behavior to PTC. Lymphocytic infiltration is often present in PTC. In this study, we sought to decipher the relationship between the BRAF and pTERT mutations and immune gene dysregulation in tumor samples from a cohort of 147 samples of PTC.MethodsThe abundance of 770 immune gene transcripts was determined by multiprex capture/detection and digital counting of mRNA transcripts using the NanoString nCounter® PanCancer Immune Profiling Panel.ResultsWe identified 40 immune transcripts differentially expressed in BRAFmutpTERTmutvs BRAFmutpTERT wildtype (pTERTwt) (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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