| Autor: |
Isabella Sundl, Montse Guardiola, Gholamali Khoschsorur, Rosa Solà, Joan C. Vallvé, Gemma Godàs, Lluís Masana, Michaela Maritschnegg, Andreas Meinitzer, Nicolas Cardinault, Johannes M. Roob, Edmond Rock, Brigitte M. Winklhofer-Roob, Josep Ribalta |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 48, Iss 11, Pp 2506-2513 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1194/jlr.M700285-JLR200 |
| Popis: |
The aim of this study was to investigate the effects of the apolipoprotein A5 (APOA5) 1131T>C gene variant on vitamin E status and lipid profile. The gene variant was determined in 297 healthy nonsmoking men aged 20–75 years and recruited in the VITAGE Project. Effects of the genotype on vitamin E in plasma, LDL, and buccal mucosa cells (BMC) as well as on cholesterol and triglyceride (TG) concentrations in plasma and apolipoprotein A-I (apoA-I), apoB, apoE, apoC-III, and plasma fatty acids were determined. Plasma malondialdehyde concentrations as a marker of in vivo lipid peroxidation were determined. C allele carriers showed significantly higher TG, VLDL, and LDL in plasma, higher cholesterol in VLDL and intermediate density lipoprotein, and higher plasma fatty acids. Plasma α-tocopherol (but not γ-tocopherol, LDL α- and γ-tocopherol, or BMC total vitamin E) was increased significantly in C allele carriers compared with homozygote T allele carriers (P = 0.02), but not after adjustment for cholesterol or TG. Plasma malondialdehyde concentrations did not differ between genotypes. In conclusion, higher plasma lipids in the TC+CC genotype are efficiently protected against lipid peroxidation by higher α-tocopherol concentrations. Lipid-standardized vitamin E should be used to reliably assess vitamin E status in genetic association studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
