Role of continuous hypertonic saline in acute ischemic infarcts: a systematic literature review

Autor:	Arunit J. S. Chugh, Marquis Maynard, Kerrin Sunshine, Berje H. Shammassian, Adam Sauer, Kolade Odetoyinbo, S. Alan Hoffer
Jazyk:	English<br />Korean
Rok vydání:	2021
Předmět:	brain edema saline solution hypertonic ischemic strokes mortality critical care outcomes Neurology. Diseases of the nervous system RC346-429
Zdroj:	Journal of Neurocritical Care, Vol 14, Iss 1, Pp 1-7 (2021)
Druh dokumentu:	article
ISSN:	2005-0348 2508-1349
DOI:	10.18700/jnc.210007
Popis:	Continuous hypertonic saline for hemispheric ischemic infarcts has been routinely used in neurocritical centers for the management of malignant cerebral edema. However, the data supporting its use are extremely limited. We present a systematic literature review that highlights five studies (one randomized control trial and four retrospective cohort) where the effects of continuous hypertonic saline were studied in patients with acute ischemic infarcts. Collectively, there is a lack of substantial evidence supporting its use. Also, this review emphasizes significant study flaws that make the conclusions largely nongeneralizable. Although the reported studies demonstrate improvement in control of intracranial pressure, there are no significant differences in neurological or functional outcomes or overall mortality.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4e27c8d2aae94b86967707412da924f8 Zobrazit plný text záznamu View record in DOAJ