| Autor: |
Manas Sarkar, Aparajita Borkotoki, Indra Baruah |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
All Results Journals: Biol, Vol 2, Iss 1, Pp 1-7 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
2172-4784 |
| Popis: |
The Voltage Gated Sodium Channel (VGSC) is critical for binding of different insecticides and plays a key role in insecticide resistance. The insect sodium channel consists of four homologous domains (I to IV), each containing six transmembrane segments (S1 to S6). An important mechanism of resistance to DDT and pyrethroids is termed knockdown resistance (kdr), caused by a single nucleotide polymorphism in IIS6 domain of sodium channels. We analyzed the polymorphisms, nucleotide diversity, and phylogenies in VGSC-IIS6 gene in Culex quinquefasciatus from India. We analyzed the neutral model / hypothesis to infer if natural selection is acting upon the analyzed vgsc gene. Tajima’s D, Fu and Li’s D* and F* and Fu’s Fs test were performed to determine whether the distribution of nucleotide variation within the samples was consistent with neutral model. We theorized that the evolutionary pattern of intra-population distribution of variability in vgsc gene is consistent with the neutral expectation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
