Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion

Autor:	Maylis Guizard, Marie Karanian, Frédérique Dijoud, Amine Bouhamama, Cécile Faure-Conter, Frédéric Hameury, Franck Tirode, Nadège Corradini
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Sarcoma Neonatal Fusion transcript Chemotherapy Cancer biology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 12, Iss 2, Pp 631-638 (2019)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000502227
Popis:	Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolution was quickly fatal. This fusion transcript has been reported in endometrial stromal sarcomas and clear cells renal sarcomas but its description in small round-cell sarcomas is recent. To our knowledge, this is the first case report describing this translocation in a newborn patient with soft tissues sarcoma and its clinical tumoral evolution.
Databáze:	Directory of Open Access Journals
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