Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis

Autor:	Michaela Andelova, Karolina Vodehnalova, Jan Krasensky, Eliska Hardubejova, Tereza Hrnciarova, Barbora Srpova, Tomas Uher, Ingrid Menkyova, Dominika Stastna, Lucie Friedova, Jiri Motyl, Jana Lizrova Preiningerova, Eva Kubala Havrdova, Bénédicte Maréchal, Mário João Fartaria, Tobias Kober, Dana Horakova, Manuela Vaneckova
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Multiple sclerosis Infratentorial lesions Spinal cord Focal and diffuse lesions thalamus Neurology. Diseases of the nervous system RC346-429
Zdroj:	BMC Neurology, Vol 22, Iss 1, Pp 1-11 (2022)
Druh dokumentu:	article
ISSN:	1471-2377
DOI:	10.1186/s12883-022-02778-z
Popis:	Abstract Background Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse spinal cord lesions remains less understood. The purpose of this study was to evaluate focal and especially diffuse spinal cord lesions in patients with early relapsing-remitting MS and their association with intracranial lesion topography, global and regional brain volume, and spinal cord volume. Methods We investigated 58 MS patients with short disease duration (
Databáze:	Directory of Open Access Journals
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