Design and Synthesis of Polyheterocyclic Compounds Containing Pyrazolopyridopyrimidine Nucleus with Antimicrobial Activities

Autor: Farag A. El‐Essawy, Mohammad Ahmad Ahmad Odah
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: ChemistryOpen, Vol 13, Iss 6, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2191-1363
20240007
DOI: 10.1002/open.202400070
Popis: Abstract This study reports the design, synthesis, and antibacterial evaluation of a library of novel polyheterocyclic derivatives featuring a unique fused pyrimidopyridopyrazole moiety. A cyclocondensation reaction between an amino−pyrazolopyridopyrimidine precursor and malonates afforded a series of pyrimidopyridopyrazolopyrimidine derivatives. Further diversification was achieved through nucleophilic cyclocondensation, yielding a collection of complex polyheterocyclic systems encompassing various ring structures. All synthesized compounds were rigorously characterized using spectroscopic techniques and elemental analysis. The antibacterial activity of the newly synthesized compounds was assessed against a panel of Gram‐positive and Gram‐negative bacteria. Notably, several compounds exhibited promising antibacterial activity, highlighting their potential as leads for the development of novel antibiotics.
Databáze: Directory of Open Access Journals
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