Prediction of aortic dilatation in surgically repaired type A dissection: A longitudinal study using computational fluid dynamicsCentral MessagePerspective

Autor: Yu Zhu, PhD, Xiao Yun Xu, PhD, Ulrich Rosendahl, MD, John Pepper, MD, PhD, Saeed Mirsadraee, MD, PhD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: JTCVS Open, Vol 9, Iss , Pp 11-27 (2022)
Druh dokumentu: article
ISSN: 2666-2736
DOI: 10.1016/j.xjon.2022.01.019
Popis: Objective: To examine the role of a key hemodynamic parameter, namely the true and false lumen pressure difference, to predict progressive aortic dilatation following type A aortic dissection (TAAD) repair. Methods: Four patients with surgically repaired TAAD with multiple follow-up computed tomography angiography scans (4-5 scans per patient; N = 18) were included. Through-plane diameter of the residual native thoracic aorta was measured in various aortic segments during the follow up period (mean follow-up: 49.6 ± 31.2 months). Computational flow analysis was performed to estimate true and false lumen pressure difference at the same locations and the correlation with aortic size change was studied using a linear mixed effects model. Results: Greater pressure difference between the true and false lumen was consistent with greater aortic diameter expansion during the follow up period (linear mixed effects analysis; coefficient, 0.26; 95% confidence interval, 0.15-0.37; P
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