SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

Autor: Qi Miao, Matthew C. Hill, Fengju Chen, Qianxing Mo, Amy T. Ku, Carlos Ramos, Elisabeth Sock, Véronique Lefebvre, Hoang Nguyen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11880-9
Popis: Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.
Databáze: Directory of Open Access Journals