Replacing 30 Gy in 10 fractions with stereotactic body radiation therapy for bone metastases: A large multi-site single institution experience 2016–2018

Autor: Erin F. Gillespie, Kaitlyn Lapen, Diana G. Wang, N. Wijetunga, Gerri L. Pastrana, Marisa A. Kollmeier, Josh Yamada, Adam M. Schmitt, Daniel S. Higginson, Max Vaynrub, Ernesto Santos Martin, Amy J. Xu, C. Jillian Tsai, Divya Yerramilli, Oren Cahlon, T. Jonathan Yang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Clinical and Translational Radiation Oncology, Vol 25, Iss , Pp 75-80 (2020)
Druh dokumentu: article
ISSN: 2405-6308
DOI: 10.1016/j.ctro.2020.10.001
Popis: Background: Bone metastases cause significant morbidity in patients with cancer, and radiation therapy (RT) is an effective treatment approach. Indications for more complex ablative techniques are emerging. We sought to evaluate RT trends at a large multi-site tertiary cancer center. Methods: Patients who received RT for bone metastases at a single institution (including regional outpatient clinics) from 2016 to 2018 were identified. Patients were grouped by RT regimen: single-fraction conventional RT (8 Gy × 1), 30 Gy in 10 fractions, SBRT, and “other”. Multinomial logistic regression was performed to assess trends in regimens over time. Binary logistic regression was performed to evaluate factors associated with receipt of SBRT. Results: Between 2016 and 2018, 5,952 RT episodes were received by 2,969 patients with bone metastases. Overall, 76% of episodes were ≤ 5 fractions. The median number of fractions planned for SBRT and non-SBRT episodes was 3 (IQR 3–3) and 5 (IQR 5–10), respectively. Use of SBRT increased from 2016 to 2018 (39% to 53%, p
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