| Autor: |
Ayushi Purohit, Bharti Kandiyal, Shakti Kumar, Agila Kumari Pragasam, Parul Kamboj, Daizee Talukdar, Jyoti Verma, Vipin Sharma, Soumalya Sarkar, Dinesh Mahajan, Rajni Yadav, Riya Ahmed, Ranjan Nanda, Madhu Dikshit, Sanjay K. Banerjee, Shalimar, Bhabatosh Das |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 27, Iss 2, Pp 108764- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.108764 |
| Popis: |
Summary: Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bidirectional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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