| Autor: |
Eric J. Cotter, MD, Lisa M. Cotter, MD, Colleen N. Riley, BA, Jonah Dixon, BS, Nicholas VanDerwerker, BS, Aniekanabasi Ime Ufot, MS, Jared Godfrey, BS, David Gold, PhD, Scott J. Hetzel, MS, Nasia Safdar, MD, PhD, Brian F. Grogan, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JSES International, Vol 8, Iss 2, Pp 328-334 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6383 |
| DOI: |
10.1016/j.jseint.2023.11.020 |
| Popis: |
Background: Blue light therapy (BLT) is a Food and Drug Administration cleared modality used in dermatology as an effective treatment of acne. The primary purpose of this study is to determine if there are dose-dependent antimicrobial effects of BLT against Cutibacterium acnes (C. acnes). Methods: A known strain of C. acnes was grown on chocolate agar in a controlled laboratory environment under anaerobic conditions for 1 week. After 1 week, 2-3 colonies of C. acnes were isolated and transferred to broth medium to incubate for 2 or 7 days. Broth vials (treatment arm) then underwent 1 of 6 different blue light dosing treatment regimens and a duplicate broth vial served as a control left open to the same environment. The BLT regimens were a single treatment of 25 J/cm2, 50 J/cm2, 75 J/cm2, 100 J/cm2, 2 serial treatments of 50 J/cm2 separated by 24 hours, or 2 serial treatments of 75 J/cm2 separated by 24 hours. The Omnilux Blue device (415 nm wavelength) was used for all BLT treatments and delivered, on average, 1.68 ± 0.004 J/min. Following treatment, the control and treatment broth samples were plated on chocolate agar and allowed to grow for 7 days. After 7 days, plates were counted and colony forming units (CFUs) were calculated. Six trials were completed for each BLT dosing regimen based on an a priori power analysis of 6 individual 2-sided t-tests. Comparisons in the primary outcome were made via mixed-effects analysis of variance with replicate as a random effect. Results: All BLT treatment regimens resulted in significantly fewer CFUs than their aggregate control plate CFUs (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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