Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

Autor: Volker Boehm, Jennifer V. Gerbracht, Marie-Charlotte Marx, Niels H. Gehring
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13691
Popis: Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay intermediates produced by several common decay pathways.
Databáze: Directory of Open Access Journals