STUDY OF THE EFFECT OF LOMUSTIN ON HER2-POSITIVE BREAST CANCER IN FVB/N HER-2 TRANSGENIC MICE

Autor:	A. N. Stukov, S. F. Vershinina, N. A. Koziavin, T. Yu. Semiglazova, L. V. Filatova, D. Kh. Latipova, A. O. Ivantsov, V. G. Bespalov, A. L. Semenov, O. A. Belyaeva, G. S. Kireeva, V. A. Alexandrov, G. V. Tochilnikov, I. N. Vasilyeva, M. A. Maydin, M. L. Tyndyk, S. S. Kruglov, G. A. Yanus, V. N. Yurova
Jazyk:	ruština
Rok vydání:	2019
Předmět:	her2-positive breast cancer her2 transgenic fvb/n mice lomustine intracranial tumor tumor growth index Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Сибирский онкологический журнал, Vol 18, Iss 5, Pp 54-60 (2019)
Druh dokumentu:	article
ISSN:	1814-4861 2312-3168
DOI:	10.21294/1814-4861-2019-18-5-54-60
Popis:	Because of the high risk of brain metastases from HER2-positive breast cancer, the study of the anticancer activity of drugs used to treat brain tumors, in particular lomustine, is of great importance. In the FVB/N Her-2 transgenic mice bearing HER2-positive breast cancer (BC HER2+), a single oral administration of lomustine at a dose of 50 mg/kg resulted in a significant tumor growth inhibition (up to 96 %, p
Databáze:	Directory of Open Access Journals
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