Patients with Allergic Rhinitis Show an Allergen-Specific Interferon-Gamma Defect
| Autor: | D. Fenoglio, A. Ferrera, F. Ferrera, M.P. Sormani, M. di Gioacchino, G. Ciprandi |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | European Journal of Inflammation, Vol 6 (2008) |
| Druh dokumentu: | article |
| ISSN: | 1721-727X 1721727X |
| DOI: | 10.1177/1721727X0800600206 |
| Popis: | Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Consequently, allergic patients have a defect in IFN-γ production. So far, however, all the experimental studies have investigated only the IFN-γ production induced by the causal allergen. The aim of this study is to investigate whether there is a difference in the in vitro IFN-γ production, using different allergens as stimuli, in patients presenting with rhinitis due to pollen allergy. Forty-one AR patients with pollen allergy were enrolled. IFN-γ-specific producing cells were stimulated with PHA, causal pollen, and House Dust Mite (HDM). IFN-γ production was assessed by cytokine ELISPOT. IFN-γ production of peripheral blood mononuclear cells (PBMC) stimulated by specific pollen was significantly lower than IFN-γ production of PBMC stimulated by HDM (p |
| Databáze: | Directory of Open Access Journals |
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