Hypothesis of COVID-19 therapy with sildenafil
| Autor: | Limodio Mario, Menicagli Roberto, Limodio Marta, Casotti Maria Teresa, Menicagli Laura |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Preventive Medicine, Vol 11, Iss 1, Pp 76-76 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2008-7802 2008-8213 |
| DOI: | 10.4103/ijpvm.IJPVM_258_20 |
| Popis: | Backgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric oxide synthase (iNOS). Excess production of this compound occurs in COVID-19 resulting in inflammatory cascade and thromboembolism. We intend to propose the use of sildenafil to reduce this production. Method: The analysis of biochemical pathways shows that viral infection produces a high amount of nitric oxide (NO), with an acute inflammatory process. Results: In the case of COVID-19 infection we verified that numerous biochemical processes activate a cascade of inflammatory processes through the activation of iNOS with uncontrolled generation of (NO). Conclusions: iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes. |
| Databáze: | Directory of Open Access Journals |
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