Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications

Autor: Nobuyoshi Kosaka, Akiko Kogure, Tomofumi Yamamoto, Fumihiko Urabe, Wataru Usuba, Marta Prieto-Vila, Takahiro Ochiya
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 51, Iss 3, Pp 1-9 (2019)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
64918041
DOI: 10.1038/s12276-019-0219-1
Popis: Cancer diagnosis: good things come in small packages Extracellular vesicles (EVs), small packets of proteins and RNAs secreted by cells and carried in the bloodstream, are promising diagnostic markers for cancer. Developing new markers that can be collected non-invasively can dramatically improve detection and treatment of cancer. EVs secreted by cells, including tumor cells, send messages to distant cells. EVs collected from blood samples can potentially be excellent disease markers. Takahiro Ochiya and Nobuyoshi Kosaka at Tokyo Medical University in Japan and co-workers have reviewed available EV technology. They report that tumors reliably secrete diagnostic EVs, revealing the origin and state of the tumor. Some EVs can even be used to predict whether a cancer might spread to another tissue. With improvement of methods for isolation and standardization, EVs could provide sensitive markers for early diagnosis of many cancers.
Databáze: Directory of Open Access Journals
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