| Autor: |
Kyoung Eun Joung, Dana Clausen, Aimee Herdt, Amy Presti, Ruth Snyder, Caryn Peters, Helen Christou, Christos S. Mantzoros |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Metabolism Open, Vol 5, Iss , Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2589-9368 |
| DOI: |
10.1016/j.metop.2020.100030 |
| Popis: |
Background: The role of fetal and neonatal growth in the development of adult-onset diseases such as obesity and metabolic syndrome has become increasingly appreciated. Fibroblast growth factor-21 (FGF-21) is known as a regulator of glucose and lipid metabolism. FGF-21 levels are elevated in obese adults and children. The role of FGF-21 in neonatal growth in preterm infants is not known. Objectives: We aimed to evaluate the association of circulating FGF-21 levels in the first week of life and neonatal growth parameters at the time of discharge from NICU. Methods: We performed a longitudinal study of 25 preterm neonates admitted to NICU. Blood samples were collected at two time points: within 24 h of life (T1), and 24–96 h after the first blood draw (T2). FGF-21 levels were measured in plasma by ELISA. Weight, length, BMI and their Z-scores were measured at the time of birth and discharge. Results: The FGF-21 levels were significantly higher at T2 than at T1 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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