In Vitro Determination of Genotoxicity Induced by Brackets Alloys in Cultures of Human Gingival Fibroblasts

Autor: Juan Pablo Loyola-Rodríguez, Ildelfonso Lastra-Corso, José Obed García-Cortés, Alejandra Loyola-Leyva, Rúben Abraham Domínguez-Pérez, David Avila-Arizmendi, Guillermo Contreras-Palma, Cecilia González-Calixto
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Toxicology, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 1687-8191
1687-8205
DOI: 10.1155/2020/1467456
Popis: Orthodontic brackets release ions that can be reabsorbed in the oral mucosa, potentially causing complications, including cytotoxic effects and mutagenic alterations. The aim was to evaluate the genotoxicity induced by orthodontic appliance alloys in cultures of human gingival fibroblasts by comet assay. Eluates were obtained from the following brackets alloys: EconoLine (SS: stainless steel), MiniMirage (Ni-Ti: nickel-titanium), Nu-Edge (Co-Cr: cobalt-chromium), In-Vu (PC-polycrystals (PC) aluminum oxide), and Monocrystal IZE (monocrystalline (MC) aluminum oxide). Each bracket was sterilized and exposed to a corrosive process for 35 days. The obtained eluates were tested for genotoxicity of human gingival fibroblasts (HGFA) by the alkaline comet assay. All study groups showed genotoxic effects; there was a significant difference (p
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