| Autor: |
Junhong Ai, Haijuan Xiao, Linlin Zhang, Honghao Ma, Dong Wang, Dilara Dilmurat, Ran Wang, Zhengde Xie |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Italian Journal of Pediatrics, Vol 50, Iss 1, Pp 1-4 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1824-7288 |
| DOI: |
10.1186/s13052-024-01783-x |
| Popis: |
Abstract Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients. A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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