SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions

Autor: Dymphie Mioch, Leonard Vanbrabant, Johan Reimerink, Sandra Kuiper, Esther Lodder, Wouter van den Bijllaardt, Jan Kluytmans, Michel D. Wissing, Hans Augustijn, Marit Bartels, Cornelia H.M. van Jaarsveld, Manon Leemans, Peter van Nierop, Natascha van Riet, Lieke Raaijmakers, Els Reisiger, Chantal Reusken, Ariene Rietveld, Sandra Salewicz
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 126, Iss , Pp 155-163 (2023)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2022.11.025
Popis: Objectives: This study aimed to evaluate dynamics of antibody levels after exposure to SARS-CoV-2 for 12 months in Dutch non-vaccinated hairdressers and hospitality staff. Methods: In this prospective cohort study, blood samples were collected every 3 months for 1 year and analyzed using a qualitative total antibody enzyme-linked immunosorbent assay (ELISA) and a quantitative immunoglobulin (Ig)G antibody ELISA. Participants completed questionnaires, providing information on demographics, health, and work. Differences in antibody levels were evaluated using Mann–Whitney U and Wilcoxon signed-rank tests. Beta coefficients (β) and 95% confidence intervals (CIs) were calculated using linear regression. Results: Ninety-five of 497 participants (19.1%) had ≥1 seropositive measurement before their last visit using the qualitative ELISA. Only 2.1% (2/95) seroreverted during follow-up. Of 95 participants, 82 (86.3%) tested IgG seropositive in the quantitative ELISA too. IgG antibody levels significantly decreased in the first months (P
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