Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

Autor: Yifeng Xia, Xiaodong Ji, In Sock Jang, Christine Surka, Christy Hsu, Kai Wang, Mark Rolfe, Neil Bence, Gang Lu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02352-2
Popis: Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line barcoding.
Databáze: Directory of Open Access Journals
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