Does oxidative status affect serum sclerostin levels in patients with type 2 diabetes mellitus?

Autor: Ilhan Sabancilar, Velid Unsal, Fidel Demir, Gulten Toprak, Zafer Pekkolay
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Folia Medica, Vol 65, Iss 1, Pp 46-52 (2023)
Druh dokumentu: article
ISSN: 1314-2143
DOI: 10.3897/folmed.65.e72953
Popis: Introduction: Sclerostin is a glycoprotein known as a negative regulator of bone formation, predominantly expressed by mature osteocytes. There is no causative evidence information on the role of sclerostin in the pathogenesis of type 2 diabetes mellitus (T2DM) in humans. Aim: This study aimed to investigate the relationship between serum sclerostin levels and oxidative status and biochemical parameters in T2DM patients and healthy people.Materials and methods: This cross-sectional study, conducted in a clinical trial center, included 45 subjects with T2DM and 45 subjects as controls.Results: Serum sclerostin, total oxidative status (TOS), albumin, and ferritin levels were significantly higher in T2DM patients than in the control group (p
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