Comparison of SUVmax values obtained from F-18 FDG PET/CT and YKL-40 levels measured from serum in the evaluation of lung lesions

Autor: Ebru Örsal İbişoğlu, Engin Şebin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Van Tıp Dergisi, Vol 28, Iss 1, Pp 38-43 (2021)
Druh dokumentu: article
ISSN: 2587-0351
DOI: 10.5505/vtd.2021.21549
Popis: INTRODUCTION: Fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography (PET)/computed tomography (CT) is a trusted method for the evaluation of cancer patients. In this study, we aimed to calculate the SUVmax values for semi-quantitative evaluation in patients with pulmonary lesions undergoing diagnostic PET / CT study and to investigate serum YKL-40 and ischemia modified albumin (IMA) levels. METHODS: We performed a prospective case-control during July 2012-July 2013. Patients referred to the nuclear medicine clinics with suspected pulmonary lesions were enrolled in the study prospectively. In this study we analyzed 85 patients who underwent ‎routine PET/CT imaging for suspicious lung masses. Of the included patients, 20 (23.5%) had BLD, while ‎‎65 (76.5%) had lung cancer (LC) in the pathological examination of the lesions. Additionally, 35 participants from the patient relatives ‎were enrolled as healthy controls. SUVmax were calculated in patients who underwent PET / CT study, and serum samples of YKL 40, IMA, carcinoembryonic antigen (CEA) and lactate dehydrogenase (LDH) values were measured. RESULTS: Patients with LC had higher mean SUVmax values compared to the BLD group (‎9.49+-2.27 vs. 3.13+-1.15) (p
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