Characteristics of Germline and Non-germline Retinoblastomas

Autor: Fariba Ghassemi, Hormoz Chams, Siamak Sabour, Reza Karkhaneh, Farzad Farzbod, Mehdi Khodaparast, Parvaneh Vosough
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Ophthalmic & Vision Research, Vol 9, Iss 2, Pp 188-194 (2014)
Druh dokumentu: article
ISSN: 2008-322X
Popis: Purpose: To discuss the clinical characteristics, treatment and outcomes of germline and non-germline retinoblastoma tumors. Methods: A retrospective study was performed on retinoblastoma cases from 1979 to 2007. General characteristics of the patients, treatment modalities, histopathological findings and survival were compared in germline versus non-germline cases. Results: We analyzed 557 cases of retinoblastoma with mean age of 32.2΁22.0 months including 177 and 380 patients with germline and non-germline tumors, respectively. Germline cases were significantly different from non-germline counterparts in terms of mean age (24.7΁17.7 vs 35.7΁23.0 months), symptoms (leukocoria in 49.4% vs 62.9%), and outcomes (death in 40.1% vs 13.9%), respectively (P
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