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BackgroundEarly natural menopause, characterized by the cessation of ovarian function before the age of 45, has been a subject of prior research indicating that inflammation may predict the onset of menopause. However, the specific relationship between peripheral blood inflammatory parameters and early natural menopause remains ambiguous.MethodsThis observational study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2013–2018. The age at menopause was ascertained through the Reproductive Health Questionnaire (RHQ), with early natural menopause defined as menopause occurring before the age of 45 years. Complete blood counts were derived from laboratory test data, and seven indices of inflammation were calculated, including lymphocyte count (LC), neutrophil count (NC), systemic immune inflammation index (SII), product of platelet and neutrophil count (PPN), platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and lymphocyte-monocyte ratio (LMR). A multivariate weighted logistic regression analysis was employed to estimate the association between these inflammatory indices and early natural menopause.ResultsA total of 2,034 participants were included in the analysis, of whom 460 reported experiencing menopause before the age of 45. Both Log2-NC and Log2-PPN were found to be positively correlated with early menopause, with odds ratios (OR) of 1.56 (95% CI: 1.16, 2.09; p = 0.005) and 1.36 (95% CI: 1.07, 1.72; p = 0.015), respectively. The results from models 1 and 2 were consistent with those from model 3. In the trend test, participants in the fourth quartile (Q4) of log2-LC exhibited a positive correlation with early menopause compared to those in the lowest quartile (Q1), with an OR of 1.41 (95% CI: 1.03, 1.93; p = 0.033). Similarly, the fourth quartile (Q4) of log2-NC and log2-PPN demonstrated a positive correlation with early menopause, with odds ratios (OR) of 1.76 (95% CI: 1.27–2.45; p |
