Therapeutic responses to chemotherapy or immunotherapy by molecular subtype in bladder cancer patients: A meta-analysis and systematic review
| Autor: | Shunde Wang, Xiaoyu Yuan, Zhongjie Shen, Jiaming Zhao, Baishu Zheng, Junyong Zhang, Chengguo Ge |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Investigative and Clinical Urology, Vol 64, Iss 3, Pp 229-241 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2466-0493 2466-054X |
| DOI: | 10.4111/icu.20230015 |
| Popis: | To systematically evaluate the differences in therapeutic response to chemotherapy or immunotherapy between different molecular subtypes of bladder cancer (BC). A comprehensive literature search was performed up to December 2021. Consensus clusters 1 (CC1), CC2 and CC3 molecular subtypes were used to perform meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the therapeutic response by fix-effect modeling. Eight studies involving 1,463 patients were included. For immunotherapy, CC3 showed the highest response rate (CC1 vs. CC3: OR=0.52, 95% CI=0.34–0.78, p=0.002; CC2 vs. CC3: OR=0.42, 95% CI=0.28-0.62, p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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