Training individuals with schizophrenia to gain volitional control of the theory of mind network with real-time fMRI: A pilot study

Autor: Elizabeth A. Kruse, Abhishek Saxena, Bridget J. Shovestul, Emily M. Dudek, Stephanie Reda, Jojo Dong, Arun Venkataraman, J. Steven Lamberti, David Dodell-Feder
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Schizophrenia Research: Cognition, Vol 38, Iss , Pp 100329- (2024)
Druh dokumentu: article
ISSN: 2215-0013
DOI: 10.1016/j.scog.2024.100329
Popis: Individuals diagnosed with schizophrenia spectrum disorders (SSDs) often demonstrate alterations in the Theory of Mind Network (ToM-N). Here, in this proof-of-concept, single-arm pilot study, we investigate whether participants with an SSD (N = 7) were able to learn to volitionally control regions of the ToM-N (dorso/middle/ventromedial prefrontal cortex [D/M/VMPFC], left temporoparietal junction [LTPJ], precuneus [PC], right superior temporal sulcus [RSTS], and right temporoparietal junction [RTPJ]) using real-time fMRI neurofeedback (rtfMRI-NF). Region-of-interest analyses demonstrate that after neurofeedback training, participants were able to gain volitional control in the following ToM-N brain regions during the transfer task, where no active feedback was given: right temporoparietal junction, precuneus, and dorso/ventromedial prefrontal cortex (neurofeedback effect Fs > 6.17, ps
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