Vasculitis damage index in Behçet’s disease

Autor: Fatema T. Elgengehy, Sherif M. Gamal, Nesreen Sobhy, Ibrahem Siam, Ahmed M. Soliman, Ghada W. Elhady, Tamer A. Gheita
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Advances in Rheumatology, Vol 61, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 2523-3106
DOI: 10.1186/s42358-021-00193-5
Popis: Abstract Background Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet’s disease (BD) to determine if VDI could be used to assess damage in patients with BD. Methods A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann–Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables. Results In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P
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