| Autor: |
Lucia K. Feldmann, Roxanne Lofredi, Wolf-Julian Neumann, Bassam Al-Fatly, Jan Roediger, Bahne H. Bahners, Petyo Nikolov, Timothy Denison, Assel Saryyeva, Joachim K. Krauss, Katharina Faust, Esther Florin, Alfons Schnitzler, Gerd-Helge Schneider, Andrea A. Kühn |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-9 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2373-8057 |
| DOI: |
10.1038/s41531-022-00301-2 |
| Popis: |
Abstract Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthalamic activity was recorded during stepwise stimulation amplitude increase OFF medication in 10 Parkinson’s patients during rest and finger tapping. Offline analysis of wavelet-transformed beta-band activity and assessment of inter-variable relationships in linear mixed effects models were implemented. There was a stepwise suppression of low-beta activity with increasing stimulation intensity (p = 0.002). Low-beta power was negatively correlated with movement speed and predictive for velocity improvements (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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