Heterochromatin organization and phase separation

Autor:	Hui Zhang, Weihua Qin, Hector Romero, Heinrich Leonhardt, M. Cristina Cardoso
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	DNA methylation heterochromatin histone H1 histone modifications HP1 liquid-liquid phase separation Genetics QH426-470 Cytology QH573-671
Zdroj:	Nucleus, Vol 14, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	19491034 1949-1042 1949-1034
DOI:	10.1080/19491034.2022.2159142
Popis:	ABSTRACTThe eukaryotic nucleus displays a variety of membraneless compartments with distinct biomolecular composition and specific cellular activities. Emerging evidence indicates that protein-based liquid–liquid phase separation (LLPS) plays an essential role in the formation and dynamic regulation of heterochromatin compartmentalization. This feature is especially conspicuous at the pericentric heterochromatin domains. In this review, we will describe our understanding of heterochromatin organization and LLPS. In addition, we will highlight the increasing importance of multivalent weak homo- and heteromolecular interactions in LLPS-mediated heterochromatin compartmentalization in the complex environment inside living cells.
Databáze:	Directory of Open Access Journals
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