Composition and concentration of serum fatty acids of phospholipids depend on tumour location and disease progression in colorectal patients
| Autor: | Bugajska Jolanta, Berska Joanna, Hodorowicz-Zaniewska Diana, Sztefko Krystyna |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Medical Biochemistry, Vol 37, Iss 1, Pp 39-45 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1452-8258 1452-8266 |
| Popis: | Background: Polyunsaturated fatty acids (PUFAs) play a role in the development/progression of colon cancer. The aim of the study was to assess the relation between serum phospholipids PUFAs, colorectal tumour localization and disease progression. Methods: A total of 67 patients (18 with proximal colon, 17 with distal colon and 32 with rectal tumour localization) as well as 16 controls were studied. One year after surgery, 33 patients had disease progression. Serum levels of C16:1(n-7), C18:1(n-9), C18:3(n-3), C20:5(n-3), C22:6(n3), C18:2(n-6), C20:2(n-6), C20:4(n-6) fatty acids of serum phospholipids were quantitatively measured before surgery by gas-chromatography. Results: Significantly higher mean value of C 18:2, as compared to control, has been noted only for patients with proximal (p< 0.05) and distal tumour (p< 0.03) localization. The lower mean level of C 20:5 and unsaturation index (UI) were observed in colorectal cancer patients regardless the tumour localization, but the statistical difference was noted only for patients with proximal tumours (p< 0.05, p |
| Databáze: | Directory of Open Access Journals |
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