Comparison of serum prostate specific antigen (PSA), soluble E-cadherin (sE-cad), and inosine monophosphate dehydrogenase-2 (IMPDH-2) as aggressive prostate cancer predictors

Autor: Ahmed Mohammed Umar, Ismaila Arzika Mungadi, Ngwobia Peter Agwu, Abdullah Abdulwahab-Ahmed, Abubakar Sadiq Muhammad, Abdullahi Khalid
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: African Journal of Urology, Vol 30, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 1961-9987
DOI: 10.1186/s12301-024-00441-2
Popis: Abstract Background This study aimed to compare serum prostate specific antigen (PSA), Soluble E-cadherin (sE-cad), and Inosine Monophosphate Dehydrogenase-2 in predicting prostate cancer aggressiveness by determining their correlations with Gleason score and International Society of Urological Pathology (ISUP) Grade Groups. Methods This was a hospital-based descriptive quantitative cross-sectional study whereby we enrolled 48 newly diagnosed prostate adenocarcinoma patients in the study. Their serum was analysed for PSA, sE-cad, and IMPDH-2. Pearson correlation coefficient was used to test the correlation between the serum sE-cad and Gleason score while Spearman rho correlation coefficient was used for PSA and IMPDH-2. The correlation coefficient (r) was graded as very weak (
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