Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles

Autor: Tetiana Ihnatova, Andriy Kaplaushenko, Yuliia Frolova, Evheniy Pryhlo
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Pharmacia, Vol 68, Iss 1, Pp 129-133 (2021)
Druh dokumentu: article
ISSN: 2603-557X
DOI: 10.3897/pharmacia.68.e53320
Popis: Novel derivatives of 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols were synthesized. The proposed approaches and developed synthetic protocols provided the possibility to design 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols and their derivatives have been shown. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of the non-enzymatic initiation of BOD with salts of iron (II). When compared with existing antioxidants, some of our compounds were found to be more potent.
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