Homoclinic and heteroclinic solutions to a hepatitis C evolution model

Autor: Telksnys Tadas, Navickas Zenonas, Marcinkevicius Romas, Cao Maosen, Ragulskis Minvydas
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Open Mathematics, Vol 16, Iss 1, Pp 1537-1555 (2018)
Druh dokumentu: article
ISSN: 2391-5455
DOI: 10.1515/math-2018-0130
Popis: Homoclinic and heteroclinic solutions to a standard hepatitis C virus (HCV) evolution model described by T. C. Reluga, H. Dahari and A. S. Perelson, (SIAM J. Appl. Math., 69 (2009), pp. 999–1023) are considered in this paper. Inverse balancing and generalized differential techniques enable derivation of necessary and sufficient existence conditions for homoclinic/heteroclinic solutions in the considered system. It is shown that homoclinic/heteroclinic solutions do appear when the considered system describes biologically significant evolution. Furthermore, it is demonstrated that the hepatitis C virus evolution model is structurally stable in the topological sense and does maintain homoclinic/heteroclinic solutions as diffusive coupling coefficients tend to zero. Computational experiments are used to illustrate the dynamics of such solutions in the hepatitis C evolution model.
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