Changes of oxidant-antioxidant parameters in small intestines from rabbits infected with E. intestinalis and E. magna

Autor: Yun Xiao Zhou, Xu Yuan, Xiao Fen Hu, Shan Shan Yang, Sheng Wei Zhong, Ting Yu Yang, Guo Tong Zhao, Yi Jie Jiang, Yong Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: World Rabbit Science, Vol 30, Iss 4, Pp 287-293 (2022)
Druh dokumentu: article
ISSN: 1257-5011
1989-8886
DOI: 10.4995/wrs.2022.17395
Popis: Rabbit coccidiosis is a very serious disease caused by protozoan parasites of the genus Eimeria, which increases the production rate of free radicals, especially reactive oxygen species. When the generation of free radicals exceeds the scavenging capacity of the body’s antioxidant system, the oxidant-antioxidant balance is broken, resulting in oxidative stress. This study was designed to investigate the effect on the oxidant-antioxidant status of rabbits infected with E. intestinalis and E. magna. To this end, eighteen 30-d-old weaned rabbits were randomly allocated into three groups as follows: the E. intestinalis infection group with 3×103 sporulated oocysts of E. intestinalis, the E. magna infection group with 20×103 sporulated oocysts of E. magna, and the uninfected control group. We measured the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) and the contents of malondialdehyde (MDA) in rabbits’ small intestinal tissues (duodenum, jejunum and ileum) of the three groups on day 8. The results showed that CAT activity and MDA levels significantly increased, while the activities of SOD, GSH-Px and T-AOC decreased after E. intestinalis and E. magna infection. Besides, the jejunum and ileum were particularly damaged in the rabbits. It is concluded that the pathological oxidative stress occurs during the E. intestinalis and E. magna infection process and the body’s oxidant-antioxidant balance is disrupted.
Databáze: Directory of Open Access Journals
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