| Autor: |
Yueqian Sun, James X. Tao, Xiong Han, Xiangqing Wang, Yulan Zhu, Yajun Lian, Guoping Ren, Qun Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Annals of Clinical and Translational Neurology, Vol 10, Iss 8, Pp 1407-1416 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2328-9503 |
| DOI: |
10.1002/acn3.51831 |
| Popis: |
Abstract Background Anti‐metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare and under‐recognized autoimmune encephalitis. This study is conducted to characterize its clinical and neuroimaging features. Methods Twenty‐nine patients with anti‐mGluR5 encephalitis (15 new cases identified in this study and 14 previously reported cases) were included in this study and their clinical features were characterized. Brain MRI volumetric analysis using FreeSurfer software was performed in 9 new patients and compared with 25 healthy controls at both early (≤6 months of onset) and chronic (>1 year of onset) disease stages. Results The common clinical manifestations of anti‐mGluR5 encephalitis included cognitive deficits (n = 21, 72.4%), behavioral and mood disturbances (n = 20, 69%), seizures (n = 16, 55.2%), and sleep disorder (n = 13, 44.8%). Tumors were observed in 7 patients. Brain MRI T2/FLAIR signal hyperintensities were observed predominantly in mesiotemporal and subcortical regions in 75.9% patients. MRI volumetric analysis demonstrated significant amygdala enlargement in both early and chronic disease stages compared to healthy controls (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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