| Autor: |
Naohide Kanemoto, Takashi Okamoto, Koji Tanabe, Takahiro Shimada, Hitomi Minoshima, Yuya Hidoh, Masashi Aoyama, Takashi Ban, Yusuke Kobayashi, Hikaru Ando, Yuki Inoue, Motohiro Itotani, Seiji Sato |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-09911-6 |
| Popis: |
Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liver-localized mitochondrial uncoupler OPC-163493, which leads to amelioration of diabetes and hypertension in several rodent disease models. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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