| Autor: |
Mutaz Amin, Claudia Gragnoli |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Aspects of Molecular Medicine, Vol 4, Iss , Pp 100046- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2949-6888 |
| DOI: |
10.1016/j.amolm.2024.100046 |
| Popis: |
Background: Type 2 diabetes mellitus (T2D) stands as one of the most prevalent chronic diseases globally, posing substantial health and economic burdens on society. Within the spectrum of T2D, familial cases emerge as a distinct entity characterized by a strong familial clustering of the disease. This phenomenon has long suggested that genetics contributes substantially to T2D susceptibility, motivating extensive research into the genetic determinants of familial T2D. Methods: We recruited 212 multigenerational Italian families with multiple cases of T2D. The families were genotyped using genomic array (≥ 600k) derived from the UK Biobank Axiom Array platform. Informative markers were tested via Pseudomarker for linkage to and linkage disequilibrium (i.e., linkage joint to association) with T2D across the following models: dominant with complete penetrance (D1), dominant with incomplete penetrance (D2), recessive with complete penetrance (R1), and recessive with incomplete penetrance (R2). Results: We identified a total of 566 variants reaching genome-wide significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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